Anti-inflammatory potential of ethanol leaf extract of Sphenocentrum jollyanum in experimental mice

Anti-inflammatory potential of the ethanol leaf extract Sphenocentrum jollyanum (ELESJ) was assessed in-vivo in mice by using carrageenan-induced paw oedema, egg albumin-induced and xylene-induced ear oedema model at doses 474.34, 948.68, 1423.03 mg/kgbw respectively. A total seventy-five matured both sexes weighing between 20 g 24 (divided into three groups 25 each for 3 different studies) were used this study. Treatment done intraperitoneally. Distilled water (10 mL/kgbw), acetylsalicylic acid (ASA) (100 mg/kgbw) or dexamethasone (4 served as normal standard drugs The results showed that ELESJ produced significant (p < 0.05), dose-dependent time-dependent reductions mean thickness III-V compared with control group. Similarly, caused a increase percentage inhibition egg-albumin induced (34.49%, 36.71%) highest dose (1423.03 mg/kg), comparable anti-inflammatory effects drug ASA (34.69%, 31.54%). also decreases weight all test relative to group In addition, inhibitory effect (44%) mg/kg) drug, (48%). obtained from study support use folk medicine it has properties may be attributed phytochemical constituents leaf.